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A 2025 in vitro study using retinal pigment epithelial cells (ARPE-19 cell line) under high-glucose conditions modeling diabetic retinopathy found that Epitalon treatment restored impaired wound healing in the cell model by inhibiting hyperglycemia-induced epithelial-mesenchymal transition (EMT) and fibrosis markers, while reducing reactive oxygen species and improving antioxidant gene expression in the cultured cells
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doi:10.1002/14651858.CD004326
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