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The efficacy of melatonin in functioning to overcome oxidative stress relates to its direct free radical scaveng- ing actions [27,28], its ability to enhance the activities of number of antioxidative enzymes [29-31], its stimulatory actions on the synthesis of another important intracellular antioxidant-glutathione [32], its efficacy to reduce elec- tron leakage from the mitochondrial electron transport chain [33] and its synergistic interactions with the other antioxidants [34]

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Soria AC, Villamiel M