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Supplementary material The Supplementary Material for this article can be found online at: References 1 AddisonR

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Given the mechanistically complex and heterogeneous nature of neurological injury, a number of factors were suggested as possible variables that contributed to the lack of translation, including suboptimal experimental models, inadequate randomization and blinding procedures, and selection of drugs with poor pharmacokinetics, limited brain penetration, and/or narrow therapeutic windows [7]