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The aromatase gene is directly regulated by CREB (107), and this enzyme converts androgens (e.g., testosterone) to estrogens, while StAR mediates the transport of cholesterol substrate to the mitochondria for synthesis of testosterone, E2 and P4 in steroidogenic cells (Figure 2)

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45 The results demonstrated an improvement in health-related quality of life, decreased respiratory exacerbations, fewer hospital days and a reduced cost of health care in the active drug group